ECS: Healthy Heart Helpers Get Buffeted at Cardiology Meeting - CME Teaching Brief - MedPage Today:
"'The homocysteine hypothesis is dead,' declared Kaare Bonaa, M.D., of the University of Tromso in Trondheim, Norway. In terms of heart disease risk, ' homocysteine is an innocent bystander,' he said at the European Society of Cardiology Congress 2005."
In the vitamin B-homocysteine arena, Dr. Bonna and colleagues enrolled 3,749 myocardial infarction patients in the Norwegian Vitamin Trial (NORVIT). Patients were randomized to high dose vitamin B, high dose folic acid, or placebo for up to three years.
As expected the high doses of vitamin B lowered circulating homocysteine by 30%, but rather than decreasing heart attack risk, "there was a 20% increase in risk of cardiovascular events," Dr. Bonaa said.""
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