Friday, April 29, 2005

Eliminating enzyme dramatically reduces cardiovascular disease

VERY interesting! Maybe it is not cholesterol but "ACAT2, a cholesterol transforming enzyme"

Eliminating enzyme dramatically reduces cardiovascular disease: "How does cholesterol in our diets end up as artery-clogging plaque that can cause heart attacks and strokes? Research in animals suggests that a little-studied enzyme may play a major role - and that drugs to target it could dramatically reduce the risk of cardiovascular disease. "

The good news is that new medicines will likely be made to target ACAT2.

The bad news? ACAT2 seems to also affect monounsaturated fats (at least in monkeys):

" Evidence suggests that a diet high in mono-unsaturated fats, which include olive oil, nuts and nut butters, avocado and sesame seeds, may stimulate transformation by ACAT2.

In a study of monkeys, those that were fed a diet high in monounsaturated fat got just as much heart disease as monkeys that were fed saturated fat, even though their levels of "bad" cholesterol decreased."

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